Autonomous de novo protein binder design with Claude

Claude Opus 4.8 and Mythos Preview ran fully autonomous 24–48 hour drug-target campaigns — no human input into any design decision — producing protein binders against 14 of 15 targets at a 27% overall hit rate and 49% for top-ranked designs; on RBX1, Claude's best binder hit KD 3.9 nM vs 45 nM for the re-synthesized human competition winner on the same plate, and it produced TNFα binders where 'multiple de novo design efforts had reported none.' All 1,440 design models, binding data, and prompts released open-source; 'Claude Science' is listed as an author.