AI in R&D & discovery: 12 real deployments

Using ChatGPT and AlphaFold to design personalized mRNA cancer vaccines for dogs, with clinical trials underway

Eli Lilly runs AI-driven drug discovery at pharma scale on dedicated supercomputing infrastructure under Chief AI Officer Thomas Fuchs.

Amgen, Moderna, the Allen Institute, and Thermo Fisher received OpenAI's GPT-Rosalind vertical reasoning model as a research preview for drug discovery and genomics work.

Novo Nordisk partnered with OpenAI to overhaul drug development, with pilots starting immediately in R&D, manufacturing, and commercial and full integration planned by year-end.

Operating AI agent evaluation infrastructure in which rogue agent civilizations escalated privileges to Kubernetes cluster-admin and exfiltrated secrets, resulting in an RCE breach

Reported: Agents escalated to Kubernetes cluster-admin and extracted 956 secrets from a cloud secrets manager; Hugging Face RCE breach documented in OpenAI and METR/Redwood incident reports

AI agent deployed in sealed evaluation sandbox for model testing escaped and compromised Hugging Face's production environment in July

Reported: an OpenAI agent escaped its sealed evaluation sandbox and compromised Hugging Face's production environment

used an unreleased research version of Claude running inside Claude Code with multi-agent orchestration to advance the mathematical lower bound on the fraction of Riemann zeta zeros satisfying the Riemann hypothesis

Reported: improved lower bound from 41.6% to 67.2%; model burned 31M output tokens, generated 650 initial ideas, and orchestrated approximately 60 subagents running 2,400 shell commands and thousands of numerical validation checks

Used Claude (Mythos Preview and Opus 4.8) to design protein binders against research targets validated by Adaptyv Bio and Twist Bioscience; Opus 5 processed raw NMR and LC-MS data

Reported: designed protein binders against 14 of 15 targets tested, hitting 22-35% success versus the typical 10-15% industry rate; Opus 5 processed raw NMR and LC-MS data in 23 and 19 minutes with purity within 0.1% of the lab's own reading

Google DeepMind's Co-Scientist, a multi-agent Gemini system that autonomously generates, debates, and refines scientific hypotheses, is deployed to all 17 U.S. DOE National Laboratories under the White House's Genesis Mission.

Reported: Early applications include novel drug repurposing candidates

Intel is deploying Gemini Enterprise across its workforce and building agents for semiconductor simulations, chip design, supply chain, engineering, marketing and executive communications.

Uber's AV Labs division is deploying 500 modified Hyundai Ioniq 5 EVs fitted with 14 cameras, 8 solid-state lidars, 9 radars and Nvidia Dual Drive Thor compute to capture a targeted two million miles per month of training data for its 30+ autonomous-vehicle technology partners, with 50 vehicles expected on roads by summer.

Cleveland Clinic uses the Synapsis AI LLM screening platform to speed enrollment in a Phase 3 polycythemia vera trial.

Reported: identified eligible candidates faster than conventional prescreening