Claude autonomously computed the six-particle scattering amplitude in planar N=4 super-Yang-Mills theory at nine loops, one loop beyond the previous human record
Reported: nine-loop result one loop beyond Lance Dixon's 2023 record; cost roughly $1,000–$2,000 on 96 CPUs over about a week; result validated by Dixon (SLAC)
Used multiple AI agents to search M23 symmetry combinations and numerically approximate candidate surfaces to solve the inverse Galois problem
Reported: produced an explicit degree-23 polynomial whose Galois group is M23, closing the final open sporadic case of the inverse Galois problem; one AI agent surfaced a workable surface the humans converted to polynomial equations
Used multiple AI agents to search M23 symmetry combinations and numerically approximate candidate surfaces to solve the inverse Galois problem
Reported: produced an explicit degree-23 polynomial whose Galois group is M23, closing the final open sporadic case of the inverse Galois problem; one AI agent surfaced a workable surface the humans converted to polynomial equations
Deploying Apollo, an Ancient Greek LLM trained on approximately 600 million words of historical Greek plus tens of thousands of papyri and inscriptions, for fill-in-the-middle restoration of damaged texts made freely available to academics
Used Claude autonomously via the Prove2Me platform to produce the first computer-checked proof of Fermat's Last Theorem in Lean over 11 days
Reported: generated 13 million lines of Lean code, proved 30,300 theorems with 29,500 used in the final proof, consumed about six billion output tokens
Using AI to generate medical systematic reviews and peer review services while advertising them as '100% human-written, never AI', with fabricated PhD staff credentials
WSU and Google built a fully automated AI pipeline for wildlife camera-trap analysis, tested across Washington, Glacier National Park and Guatemala's Maya Biosphere Reserve.
Reported: Camera-trap analysis cut from seven months to under a week; matched human ecologists in 85-90% of cases.
Launching experimental Project Suncatcher satellite carrying four TPUs into low Earth orbit for approximately one year as first hardware step toward kilometer-scale orbital AI compute clusters
Deployed approximately 950 Claude agents to autonomously scan bacteriophage reverse transcriptases and identify novel enzyme systems in its new life sciences research group
Reported: 950 agents ran for 21 hours using 210M tokens to scan 200,000 RTs and narrow 3,500 candidates to 20 systems, discovering array-associated reverse transcriptases (ART), a previously uncharacterized CRISPR-like bacteriophage enzyme system
Used Claude (Mythos Preview and Opus 4.8) to design protein binders against research targets validated by Adaptyv Bio and Twist Bioscience; Opus 5 processed raw NMR and LC-MS data
Reported: designed protein binders against 14 of 15 targets tested, hitting 22-35% success versus the typical 10-15% industry rate; Opus 5 processed raw NMR and LC-MS data in 23 and 19 minutes with purity within 0.1% of the lab's own reading
Google DeepMind's Co-Scientist, a multi-agent Gemini system that autonomously generates, debates, and refines scientific hypotheses, is deployed to all 17 U.S. DOE National Laboratories under the White House's Genesis Mission.
Reported: Early applications include novel drug repurposing candidates
Every entry names the organisation and links its source. Outcome figures are quoted as reported, never estimated. Vendor announcements without a named customer are excluded. Halted and reversed deployments are kept on purpose.
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